All smooth simple closed curves in $\mathbb R^3$ (knotted or not) can be isometrically embedded into $\mathbb R^2$ as a circle of equal arclength.
The situation for knotted spheres seems more complicated because metric surfaces are more rigid. Here I am unsure that if given a smooth knotted sphere in $\mathbb R^4$ if there is a way to embed into $\mathbb R^3$ while preserving its metric structure. So my question is:
Does there exist a nontrivial smooth knotted sphere in $\mathbb R^4$ which can be smoothly isometrically embedded into $\mathbb R^3$? And if so, are there any concrete examples?
In all of the above, the Riemannian metric structures are assumed to be inherited from the ambient space.