Q. Is there a single, clear mathematical question that has emerged as the open problem in General Relativity?
I ask this on the ~100th anniversary of Einstein's (4-page!) 1915 paper,
"Die Feldgleichungen der Gravitation," Preussische Akademie der Wissenschaften, Sitzungsberichte, 1915 (part 2), 844–847. (Wikisource:The Field Equations of Gravitation.)
Einstein's notebook, Riemann curvature tensor.
It is difficult to surpass Willie Wong's thorough 2011 answer to the MSE question, "Open problems in General Relativity." But perhaps a core mathematical question has risen to the fore since?
Naked singularities? Beyond the Cauchy horizon? "Electrodynamics of moving bodies?" Florentin Smarandache's 2013 Unsolved Problems in Special and General Relativity (PDF download.)?
Or perhaps Willie's inventory cannot be condensed or sorted further at this point in time?