If $\mathcal{X}$ is a smooth cutoff near 0 in $\mathbb{R}^n$, then $M_0 = \mathcal{X}(-\Delta+Id)\mathcal{X}$ is a self-adjoint operator in $L^2(\mathbb{R}^n)$. Because $M_0$ is semi-positive and the spectral theory of self-adjoint operator, we can define $M_0^{n/4+\epsilon}$. I need an inequality $$\|M_0^{n/4+\epsilon}u\|_{L^2(\mathbb{R}^n)}\geq C\epsilon^{-1/2}|u(0)|\ \,\,\,\,\ \ \forall\epsilon>0$$
The difficulty of this inequality is local and fractional. And the power of $\epsilon$ can be gotten by using Fourier transform and suppose $\mathcal{X}\equiv1$. I met this inequality in a paper of P.Lax, he uses this to get a global inequality in manifold.