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Is the connecting map $\pi_2(B) \to \pi_1(F)$ ever nonzero in smooth proper families?

Suppose that $X, B$ are smooth irreducible varieties over $\mathbb{C}$ and $f : X \to B$ is a smooth proper morphism. Then we can consider the homotopy exact sequence: $$ \pi_2(B) \to \pi_1(F) \to \...
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