By the Lickorish-Wallace theorem, every oriented closed $3$-manifold can be obtained by a surgery on a link in $S^3$. In the statement of this result, links are required: not every such manifold can be obtained by a surgery on a knot in $S^3$. One way to see this is that $H_1(S^3_{p/q}(K))$ is cyclic for any knot.
- What are some other necessary or sufficient conditions on a $3$-manifold to be a surgery on a knot in $S^3$?
The same question can be asked if we restrict ourselves to $\mathbb{Z}HS^3$. I am aware of some strengthenings of the Lickorish-Wallace theorem from the work of Hilden and Matveev, but they still require links.
- What is some $\mathbb{Z}HS^3$ that cannot be obtained by a surgery on a knot in $S^3$? Is there a characterization of $\mathbb{Z}HS^3$s that can be obtained by a surgery on a knot in $S^3$? If not, what are some necessary or sufficient conditions?
I know that these questions are equivalent to asking which surgery diagrams can be reduced to knots by the Kirby moves, so I do not expect a complete classification exists.
- Are there any partial results for branched double covers of knots?