Helo,
I am still interested in the asymptotic behavior of certain sums of type $\sum_{k=1}^{n}\left\{ \frac{h(n)}{h(k)}\right\}$ and here I conjecture that we have
$$\sum_{k=1}^{n}\left\{ \frac{2^{n}+1}{2^{k}+1}\right\}=\log(2)n+O \left(n^{1/2}\right)$$
where $\{x\}$ is the fractional part of $x$. But I had little trouble showing it. I manage to get
$$\sum_{n/2<k\leq n}\left\{ \frac{2^{n}+1}{2^{k}+1}\right\} =n/2+O\left (1\right)$$
and relationships
$\left\lfloor \frac{n+1}{2}\right\rfloor \leq k\leq n-1\Longrightarrow \left\{\frac{2^{n}+1}{2^{k} +1}\right\}=\frac{2^{k}+2-2^{n-k}}{2^{k}+1}$
$\left\lfloor \frac{n+3}{3}\right\rfloor \leq k\leq\left\lfloor \frac{n}{2}\right\rfloor \Longrightarrow \left\{\frac{2^{n}+1}{2^{k} +1}\right\}=\frac{2^{n-k}+1}{2^{k}+1}$
but that is not enough for me to conclude. Thanks for your help.