This is actually the weighted AM-GM inequality for $n = 2$ in disguise. Recall that this inequality says that if $w_1, w_2$ are two non-negative weights such that $w_1 + w_2 = 1$ and $x_1, x_2 \ge 0$, then
$$w_1 x_1 + w_2 x_2 \ge x_1^{w_1} x_2^{w_2}.$$
Now set $w_1 = \frac{1}{p}, w_2 = \frac{1}{q}, x_1 = x^p, x_2 = y^q$. The significance of the condition $w_1 + w_2 = 1$ is to ensure that the LHS is a weighted version of the arithmetic mean $\frac{x_1 + x_2}{2}$ (which we get when $w_1 = w_2 = \frac{1}{2}$) while the RHS is a weighted version of the geometric mean $\sqrt{x_1 x_2}$ (same). In particular it is necessary for the inequality to become an equality when $x_1 = x_2$, as in that case any mean should just return the common value. It is also necessary in order for the inequality to have a scaling symmetry $(x_1, x_2) \mapsto (\lambda x_1, \lambda x_2)$ (equivalent to the one Terence Tao discusses in the comments but a little easier to see in this different set of coordinates).
The weighted AM-GM inequality actually follows from the ordinary one, as follows. Recall that the ordinary AM-GM inequality says that if $y_1, \dots y_n \ge 0$ then
$$\frac{y_1 + \dots + y_n}{n} \ge \sqrt[n]{y_1 \dots y_n}.$$
This is classic and has many proofs, many of which don't involve calculus; I particularly like Cauchy's proof which reduces to the case that $n$ is a power of $2$, and then reduces further to the case $n = 2$, where it is just the observation that $(\sqrt{y_1} - \sqrt{y_2})^2 \ge 0$.
Now apply the ordinary AM-GM inequality to a collection of $k_i$ copies of another set of variables $x_i$. This gives
$$\frac{k_1 x_1 + \dots + k_n x_n}{k_1 + \dots + k_n} \ge \sqrt[k_1 + \dots + k_n]{x_1^{k_1} \dots x_n^{k_n}}.$$
Setting $w_i = \frac{k_i}{k_1 + \dots + k_n}$ we get weighted AM-GM for rational weights. Now weighted AM-GM for arbitrary weights follows by continuity. This argument does not require computing a single derivative!