Let $C$ be a compact and totally-disconnected subspace of the $n$-sphere $\mathbb{S}^n$, where $n\geq 2$.
Question: Must the Freudenthal compactification of $\mathbb{S}^n \setminus C$ be homeomorphic to $\mathbb{S}^n$?
The case where $C$ is homeomorphic to the Cantor set is interesting.
For $n=2$ the answer is yes, see e.g. Corollary 1.5. in Georgakopoulos - On planar Cayley graphs and Kleinian groups. For $n=3$ I suspect it is still easy using a triangulation of $\mathbb{S}^n \setminus C$.