There is a Serre dualizing complex $S_X\in D^b Coh(X)$ for any scheme $X$ of finite type. For proper schemes, it is characterized as the sheaf defining the right adjoint to derived global sections, and for a general scheme $U$, one can define $S_U: = j^*S_X$ for $j:U\to X$ the open embedding into some choice of compactification $X\supset U.$
Now given a scheme $X$ over $\mathbb{C},$ Serre's GAGA associates to it a ringed space $(X(\mathbb{C}), \mathbb{O}^{hol})$ of holomorphic sections on the topological space $X(\mathbb{C})$ with analytic topology. When $U$ is a smooth $n$-dimensional scheme, we have a canonical quasiisomorphism $$S_X \cong \omega_X[-n]$$ for the Serre dualizing complex in terms of the sheaf of top forms $\omega : = \Omega^n(X)$, which is an analytic invariant. I am interested in whether this continues to be true for singular schemes. I.e., I would like to know the following.
Question. Suppose $X$ is a scheme of finite type over $\mathbb{C}$ and $\underline{U}\subset X(\mathbb{C})$ is an analytic open. Is there an invariant of the ringed space $(\underline{U}, \mathbb{O}^{hol}\mid U)$ which recovers the holomorphic sections of the Serre dualizing sheaf $S_X^{hol}\mid \underline{U}$?