MO question 19282 is about integral epimorphisms of commutative rings, and a counterexample is given to surjectivity. What about the case of the Frobenius endomorphism of a commutative, characteristic $p$ ring $R$: if it is epimorphic, is it surjective ?
This comes up naturally when one considers the Frobenius twist functor on $R$-algebras, its right adjoint, and especially the question whether the unit and counit of this adjunction are isomorphisms.