$\newcommand{\GL}{\operatorname{GL}}$
Let $H_{>k}$ be the space of real $d \times d$ matrices of rank bigger than $k$, for some fixed $k$. $H_{>k}$ is an open connected submanifold of $ \mathbb{R}^{d^2}$.
Question: Does $H_{>k}$ admit a transitive Lie group action? (by a "Lie group" I mean a finite dimeniosnal one).
A manifold that admits a transitive Lie group action has finitely-generated homotopy groups $\pi_n$ for $n\ge 2$-and $H_{>k}$ satisfies this necessary condition.
There is an action on $H_{>k}$ by $\GL(n) \times \GL(n)$, given by $$ (A,B) \cdot C=ACB^{-1}. $$
The orbits correspond to the different ranks. Even if there is a transitive action, I don't expect it to be as "natural".