None of the Harmonic numbers $H_n = \sum_{k=1}^n 1/k$ are integers for $n>1$ (e.g., this MSE question and answer).
Q. Define the $r$-th root Harmonic number $H_n^{1/r} = \sum_{k=1}^n 1/{k^{1/r}}$. E.g., for $r=2$, $H_n^{1/2} = \sum_{k=1}^n 1/\sqrt{k}$. Is $H_n^{1/r}$ ever an integer for $n>1$ and $r \ge 2$ an integer?
Of course there are many close calls, e.g., $H_{202}^{1/2} \approx 27.0002$, $H_{1132}^{1/3} \approx 162.00004$, $H_{222}^{1/4} \approx 76.000003$.
Answered in comments by Vesselin Dimitrov: No. In fact all these sums are irrational.