Here is a positive result. Every finite-dimensional algebra $A$ over a field $K$ has an intrinsic determinant, and in fact an intrinsic characteristic polynomial, which is preserved by all automorphisms. The obvious choice is to consider, for each $a \in A$, the action $L_a : A \to A$ of $a$ on $A$ by left multiplication, and take the characteristic polynomial and determinant of $L_a$. This works (it is preserved by all automorphisms), but it isn't the intrinsic choice, e.g. it doesn't reproduce the usual determinant and characteristic polynomial when applied to $A = M_n$ itself.
The intrinsic characteristic polynomial can instead be defined as the minimal polynomial of the generic element of $A$, which means explicitly: choose a basis $a_1, \dots a_n \in A$, and consider the minimal polynomial of the element
$$a = \sum x_i a_i \in A \otimes_K K(x_1, \dots x_n)$$
over $K(x_1, \dots x_n)$. This turns out to be a monic polynomial $\chi_a$ with coefficients in $K[x_1, \dots x_n]$, and by definition it is satisfied by every element of $A$ (once we specialize the $x_i$ to elements of $K$). So in other words we start from the Cayley-Hamilton theorem. A more abstract definition that makes it clearer that this is invariant under automorphisms is to begin with the counit as an element of $A \otimes A^{\ast}$, and embed this into $A \otimes Q(S(A^{\ast}))$ where $S$ is the symmetric algebra and $Q$ is the fraction field. From here we can define the intrinsic determinant
$$\det a = (-1)^{\deg \chi_a} \chi_a(0).$$
I learned this approach from Skip Garibaldi's The characteristic polynomial and determinant are not ad hoc constructions
. It produces, for example, the correct "reduced" determinant of a quaternion $q = a + bi + cj + dk$, namely
$$\det q = q^{\ast} q = a^2 + b^2 + c^2 + d^2$$
(the characteristic polynomial ends up being $(t - q)(t -q^{\ast})$), whereas considering left multiplication produces the square of this determinant.
The intrinsic determinant on $\mathbb{C} \times \mathbb{C}$ turns out to agree with the determinant of left multiplication, and is just $\det(a, b) = ab$. To show this we just need to show that the characteristic polynomial of $(a, b)$ is $(t - a)(t - b)$.