Given 2-tangles $T_1,T_2\subset B^3$ with their endpoints at some fixed points NW, NE, SW, SE of $\partial B^3$ we can glue them along $\partial B^3$ to obtain a link $L=T_1\cup T_2\subset S^3.$
Q: Does that link $L$ together with $T_1$ determine the homeomorphism class of $(B^3,T_2)$?
Remarks
- Note that $L$ and $T_1$ do not determine the isotopy class of $T_2$ (within the space of tangles with endpoints at NW, NE, SW, SE, fixed on $\partial B^3$).
- More generally, any 3-manifolds $M_1,M_2$ glued along their boundaries or partial boundaries, $S\hookrightarrow M_1, S\hookrightarrow M_2$, form a 3-manifold $N=M_1\cup_S M_2$. However $N$ and $M_1$ do not determine the homeomorphism class of $M_2$ in general.