Volume computation is $\#P$ hard.
Take the $[0,1]^n$ polytope.
Slice it by an half space inequality with $poly(n)$ bit rational coefficients into two unequal halves.
Volume of bigger section is $\frac12+\epsilon$ where $\epsilon\in(0,\frac12)$ holds.
Is there an efficient polynomial time deterministic algorithm to find $\frac pq$ where each integer $p$ and $q$ are of $poly(n)$ bits so that we can achieve $|\frac pq-\epsilon|<\frac1{poly(n)}$?
Related Diophantine problem is if each integer $p$ and $q$ are of $poly(n)$ bits then what is the smallest $$|\frac pq-\epsilon|$$ we can achieve regardless of being bound in polynomial time when the half space inequality has $poly(n)$ bit rational coefficients?