It is well known that Grayson's dumbbell neck-pinch1,2 separates into disconnected pieces under mean curvature flow:
Image source: Simplicial Ricci Flow. (For contrast, see the earlier MO question, Intuition behind the Ricci flow.)
Intuitively, it seems there might be another route to morph any genus-zero surface embedded in $\mathbb{R}^3$ to a round sphere, via "inflation." Imagine slowly pumping air into the surface, attempting to inflate it to a sphere. Treat the surface as elastic/stretchable, but do not allow the surface to pass through itself—it should remain embedded. This would certainly work for the dumbbell, but might get stuck for a pretzel-twisted surface. I wonder if rendering the surface "slippery"—zero surface-to-surface friction—would prevent it from getting stuck.
Q. Has some notion of inflating a surface (analogous to mean-curvature flow shrinking) been explored? And perhaps found wanting?
I realize this question is not formalized, but I suspect the experts can answer despite its vagueness.
1M. A. Grayson, "A short note on the evolution of a surface by its mean curvature," Duke Math. J. 58 (3) (1989) 555–558. (Euclid link.)
2Tobias Holck Colding, William P. Minicozzi II and Erik Kjær Pedersen. "Mean curvature flow." Bull. Amer. Math. Soc. 52 (2015), 297-333. (AMS link.)