For reasons I'll explain at the end, I'm not certain this one qualifies, but here goes:
In 1934, Romanoff (sometimes spelled "Romanov") proved that the integers of the form $2^k+p$ ($p$ being a prime) have positive density. He asked whether there are infinitely many odd numbers that are not of the form $2^k+p$. In 1950, Erdős was the first to give the affirmative answer to this question; in fact, he produced an arithmetic progression of odd numbers, none of them of the form $2^k+p$.
His proof, in its entirety, is this:
"Clearly every integer satisfies at least one of the following congruences: $0\bmod2$, $0\bmod3$, $1\bmod4$, $3\bmod8$, $7\bmod{12}$, $23\bmod{24}$. Therefore, if $x$ is congruent to $1\bmod2$, $1\bmod7$, $2\bmod5$, $2^3\bmod{17}$, $2^7\bmod{13}$, and $2^{23}\bmod{241}$, then for any $k$, $x-2^k$ is a multiple of (at least) one of the primes $3$, $5$, $7$, $13$, $17$, $241$."
To see how this works, say, for example, that $k\equiv3\bmod8$. Then $2^k\equiv2^3\equiv x\bmod{17}$, so $x-2^k$ is a multiple of $17$, so there is no prime $p$ such that $x=2^k+p$.
By the Chinese Remainder Theorem, there is an infinite arithmetic progression of odd numbers $x$ satisfying all six of the given congruences, hence, not of the form $2^k+p$, $p$ prime.
Odd numbers not of form $p + 2^k$ are tabulated at https://oeis.org/A006285 along with many links to the literature.
The Erdős paper is On integers of the form $2^k+p$ and some related problems, Summa Brasiliensis Mathematicae 2 (1950) 113-123, available at https://users.renyi.hu/~p_erdos/1950-07.pdf.
Now, here's why I'm not certain that this qualifies. I don't know when Romanoff asked whether there were infinitely many odd numbers not of the form $2^k+p$. I haven't actually read the 1934 paper, so I don't know whether the question is there. Erdős doesn't cite the 1934 paper for the question; he just writes, "personal communication". So, it's possible that fewer than ten years passed between the publication of the question, and the solution by Erdős.