Here is a positive answer to Q1.
Step 1: Without loss of generality, each $X_i$ is symmetrically distributed. Indeed, consider an independent copy $X_i'$ of the family $X_i$ with the same joint distribution. Then
$$
E\left|\sum_i X_i\right|^p\le E\left|\sum_i (X_i-X_i')\right|^p
$$
(only the mean $0$ property and the convexity of $x\mapsto |x|^p$ are used here) while
$$
E|X_i-X_i'|^p\le 2^p E|X_i|^p
$$
and $X_i-X_i'$ are still pairwise independent.
Now choose $Q>0$ so that $Q^{2-p}=2$. Clearly, $Q\ge 2$. Define $X_{i,k}=X_i$ if $Q^k\le|X_i|< Q^{k+1}$ and $0$ otherwise ($k\in\mathbb Z$). Also denote by $Y_{\ell,k}$ the characteristic function of the event $Q^{\ell+k}\le\left|\sum_i X_{i,k}\right|<Q^{\ell+k+1}$ ($\ell\in\mathbb Z$).
Step 2: The key estimates:
When $\ell\ge 0$, we have
$$
E\left[Y_{\ell,k}\left|\sum_i X_{i,k}\right|^p\right]\le Q^{(p-2)(\ell+k)}E\left|\sum_i X_{i,k}\right|^2
\\
=Q^{(p-2)(\ell+k)}\sum_i E\left|X_{i,k}\right|^2\le 2Q^{(p-2)\ell}\sum_i E|X_{i,k}|^p=2^{1-\ell}\sum_i E|X_{i,k}|^p
$$
because $Q^{(p-2)k}|x|^2\le 2|x|^p$ when $x=0$ or $Q^k\le|x|<Q^{k+1}$.
If $\ell<0$, then
$$
E\left[Y_{\ell,k}\left|\sum_i X_{i,k}\right|^p\right]\le Q^{p(\ell+1)}\sum_i E|X_{i,k}|^p\le 2^{1+\ell}\sum_i E|X_{i,k}|^p
$$
merely because the absolute value of the sum (if not zero) is less than $Q^{\ell+1}$ times the absolute value of any non-zero term in it.
Step 3: Summing over k with fixed $\ell$. The crucial point here is that if we have any sequence of random variables $F_k$ such that the absolute value of $F_k$ is either $0$ or between $Q^{\ell+k}$ and $Q^{\ell+k+1}$, then
$$
\left|\sum_k F_k\right|^p\le 4^p\max_k|F_k|^p\le 4^p\sum_k|F_k|^p\,.
$$
It follows that
$$
E\left|\sum_k \left[Y_{\ell,k}\sum_i X_{i,k}\right]\right|^p\le 4^p\cdot 2^{1-|\ell|}\sum_k \sum_i E|X_{i,k}|^p= 4^p\cdot 2^{1-|\ell|}\sum_i E|X_{i}|^p\,,
$$
i.e.,
$$
\left\|\sum_k \left[Y_{\ell,k}\sum_i X_{i,k}\right]\right\|_{L^p}\le 4\cdot 2^{(1-|\ell|)/p}\left[\sum_i E|X_{i}|^p\right]^{1/p}\,.
$$
Step 4: Use Minkowski's inequality when summing over $\ell$ now and observe that
$$
\sum_\ell\sum_k \left[Y_{\ell,k}\sum_i X_{i,k}\right]=\sum_i X_i\,.
$$
Edit: Chasing the constant.
The technique outlined above is often useful as a replacement of interpolation when the latter fails to work directly for some reason. However, in this case we can utilize the complex interpolation tool in its original form for symmetric random variables. Here is how it can be done (I'll even assume that $X_i$ are complex, though it does not matter):
Normalize the variables so that $\sum_i E|X_i|^p=1$. Write each $X_i$ as $e^{\frac 1pG_i}u_i$ with real $G_i$ and $|u_i|=1$ so $\sum_i Ee^{G_i}=1$. Also choose $Y=e^{\frac 1qH}v$ so that $E|Y|^q=Ee^{H}=1$ and
$$
E(Y\sum_i X_i)=\left\|\sum_i X_i\right\|_{L^p}\,.
$$
Now just consider $X_{i,z}=e^{zG_i}u_i$ and $Y_z=e^{(1-z)H}v$ as in the classical proof of the Riesz-Thorin interpolation theorem. The trick is that this modification of $X_i$ does not preserve the mean $0$ property in general but does preserve symmetry (which informally merely means that for every given value of $G_i$ we have every value of $u_i$ together with its opposite). Also, since $X_{i,z}$ is constructed based on the values of $X_i$ alone, the pairwise independence is also preserved.
Now we can consider $F(z)=E(Y_z\sum_i X_{i,z})$ as an analytic in the strip $\frac 12\le\Re z\le 1$ function, as usual, and use the trivial endpoint estimates ($p=1$ and $p=2$) to get the whole range with constant $1$ for the symmetric case.
The crude reduction to the symmetric case yields then the extra factor $2^p$, but it one thinks for just a moment, one realizes that this constant is actually improving, not deteriorating, as we move from $1$ to $2$. So the question becomes the following:
Let $a_p$ and $A_p$ be the best constants in the inequality
$$
a_pE|Z|^p \le E|Z-Z'|^p\le A_pE|Z|^p
$$
where $Z$ is a mean $0$ random variable (real, complex, or Hilbert-space valued: it should, probably, be irrelevant though the original question was about the real case). What is the ratio $A_p/a_p$? It is easy to see that $a_1=1$ while $A_1=2$ explaining the jump discontinuity at $1+$, but it is also easy to see that $a_p,A_p\to 2$ as $p\to 2$, so there is no discontinuity there. I suspect that those values are just known, so I'll wait a bit before thinking of what I can prove myself here.
Edit 2. Two more remarks.
- One can also prove by complex interpolation a slightly more general inequality
$$
E\left|\sum_i(X_i-EX_i)\right|\le 2^{2-p}\sum_iE|X_i|^p
$$
for arbitrary $X_i$ (not necessarily mean $0$). All it takes is to notice that $X_{i,z}-EX_{i,z}$ depends on $z$ analytically as well. This circumvents the reduction to the symmetric case though the symmetric case with sharp constant $1$ may be of interest by itself.
Edit: Adding some details by Iosif's request:
For a random variable $X$, define $X_{i,z}=X^{[pz]}-EX^{[pz]}$ (with $X^{[pz]}$ defined as in Iosif's post). Put $S_z=\sum_i X_{i,z}=\sum_i(X_i^{[pz]}-EX_i^{[pz]})$. Then $X_{i,1/p}=X_i-EX_i$ and $S_{1/p}=S=\sum_i(X_i-EX_i)$. Put $Y_z$ to be exactly the same as in Iosif's post and define
$$
F(z)=E \bar Y^{[q(1-z)]}S_z
$$
Then $F(1/p)=\|S\|_p$ while for $\Re z=1$, we have $|F(z)|\le 2$ ($\|Y_z\|_\infty\le 1$ and $\|\sum_i X_{i,z}\|_1\le 2$), while for $\Re z=1/2$, we have $\|Y_z\|_2\le 1$ and $\|S_z\|_2^2=\sum_i\|X_{i,z}\|^2\le\sum_i\|X_i^{[pz]}\|_2^2=1$, so $|F(z)|\le 1$ ($X_{i,z}$ are independent mean zero, hence orthogonal, and subtracting the mean can only reduce the $L^2$-norm (but can raise the $L^1$-norm twice)).
Now consider $F(z)2^{1-2z}$ ($z-1$ in the comment was a typo). This function is bounded by $1$ on both lines, so everywhere. For $z=1/p$, this gives
$$
\|S\|_p=F(1/p)=2^{\frac 2p-1}(F(1/p)2^{1-\frac 2p})\le 2^{\frac 2p-1}
$$
and, raising both sides to the $p$-th power, we get
$$
E|S|^p\le 2^{2-p}\,.,
$$
- Let $\varepsilon>0$. Consider $m$ sets $F_i$ of measure $\epsilon$ with pairvise intersections of measure $\varepsilon^2$ but no triple intersections (they are easy to construct by induction when $m\varepsilon<1$). Then $X_i=\chi_{F_i}-\varepsilon$ are pairwise independent with mean $0$ and $E|X_i|^p=\varepsilon(1-\varepsilon)^p+(1-\varepsilon)\varepsilon^p$. On the other hand,
$$
E\left|\sum_i X_i\right|^p=
\\
m(\varepsilon-(m-1)\varepsilon^2)(1-m\varepsilon)^p+\frac{m(m-1)}2\varepsilon^2(2-m\varepsilon)^p
\\
+\left(1-m\varepsilon+\frac{m(m-1)}2\varepsilon^2\right)(m\varepsilon)^p\,.
$$
Considering the regime $\varepsilon\to 0$, $m\varepsilon\to x\in(0,1)$, we get
$$
(x-x^2)(1-x)^p+\tfrac{x^2}2(2-x)^p+(1-x+\tfrac{x^2}2)x^p\le C_p x\,.
$$
Thus,
$$
C_p\ge (1-x)^{p+1}+\tfrac x2(2-x)^p+(1-x+\tfrac{x^2}2)x^{p-1}
$$
for every $x\in(0,1)$.
The graph of the maximum of the RHS over $x\in(0,1)$ is below (in red) compared to $2^{2-p}$ (in green) but it is clear that for $x$ close to $0$ the RHS tends to a number close to $2$ when $p\to 1$ (the first and the third term will be about $1$ each), so $C_{1+}=2$.