Imagine that alien civilization contacted you and offered to answer one math question. This should be a Yes/No question (so, you cannot ask for a million-digit binary string encoding the answers to a million questions), and the answer will be "Yes", "No", or some impossibility statement like "Independent from ZFC". The answer will come together with a proof (if it exists).
So, what would you ask?
Obvious candidates are millennium prize problems like P vs NP. However, it seems that it is better to ask "Is public-key cryptography possible?" The answer is believed to be "Yes", and if so, it implies that P is not equal to NP, and much more. However, there may be an even better questions in this area.
If you work in number theory, you can ask about Riemann hypothesis, which would give you a lot of information about prime numbers distribution (and more!), but an obvious better question is generalized Riemann hypothesis. If we talk about prime numbers then what is a well-believed conjecture that implies the most information about their distribution? Ideally, it would be best to have the result in the form "If property P satisfies some minimal sufficient conditions, and is true in this random model of primes, then it is true for primes". This would resolve all main problems about primes including Landau's problems at once, but I am not aware about any formal conjecture in these lines.
Of course, the above areas (computational complexity and number theory) are just examples, and questions from all areas of mathematics are welcome.
Let us put aside discussion whether any hint from aliens is good for the development of mathematics. What I am asking is a single Yes/No question that gives us most. If we ask question such that only one answer (say, "Yes") have strong consequences, then we should have all the reasons to believe that the true answer is indeed "Yes". Alternatively, it may be a win-win question such that both Yes and No answers are very informative.