EDIT: According to some comments on this post I revise the title to remove the misunderestanding.
Assume that $M$ is a Riemannian manifold of dimension $n$. The natural Laplace operator associated to the metric is denoted by $\Delta$.
Are there $n$ vector fields $X_{1},X_{2}, \ldots, X_{n}$ such that $\Delta=\sum \partial^{2}/\partial X _{i}^{2}$?
Are there some local obstructions?(However our question search for global vector fields $X_{i}s$)
The obvious motivation for this question is the usual metric on $\mathbb{R}^{n}$