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Mathematics of image processing, variational methods (i.e. methods from calculus of variations), questions about denoising, deblurring, segmentation, image registration, imaging modalities (e.g. computed tomography, ultrasound, magnetic resonance tomography)

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Analytically compare two 3D heatmaps of the brain

I have two heatmaps of a 3D model of the brain, with the color of each pixel being an intensity of the response to a stimulus, and I want to get a metric of how "alike" those two heatmaps are, what ca …