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Higher cohomology of projective bundles

Let $C$ be a curve and $L$ be a line bundle with sufficiently large degree. Let $C_p$ denote the $p$-th symmetric product of $C$, which consists of all the effective divisors of degree $p$ on $C$. Let ...
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How to increase the second cohomology group of the structure sheaf?

We know that $H^2(\mathcal{O}_{\mathbb{P}^3})=0$. I am looking for blow-ups $$\pi:X \to \mathbb{P}^3$$ such that $X$ is non-singular and $H^2(\mathcal{O}_X)>0$. Of course, if we blow-up along ...
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