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nauty/traces orbit sizes for colored graph?

I'm given a graph $G$ (<1000 vertices, large automorphism group), and a large number (~10^6-10^10) of different colorings of said graph. I have two tasks. Calculate the canonical coloring. I can ...
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Generating sets of the symmetric group that yield isomorphic Cayley graphs

Let $S$ and $S'$ be subsets of size $k$ of $\mathfrak{S}_n$. Are there any necessary or sufficient conditions to determine whether or not $S$ and $S'$ yield isomorphic Cayley graphs? Assuming we ...