As observed in comments, it suffices to show that for fixed $m,k$, there are only finitely many solutions in non-negative integers to the equation
$$ a^{x_1} + \dots + a^{x_m} = b^{y_1} + \dots + b^{y_k}. \tag{1}$$
To prove this we can assume inductively that the claim is already proven for smaller values of $m+k$. In particular we can assume that no non-trivial subsum of the $a^{x_1},\dots,a^{x_m}$ agrees with no non-trivial subsum of the $b^{y_1},\dots,b^{y_k}$, since this would split the above equation (1) into two equations of the form (1) with smaller values of $m+k$, and this would only generate finitely many solutions to (1) by the induction hypothesis.
Let $S$ denote the set of primes dividing at least one of $a$ or $b$, and define an integer $S$-unit to be a (rational) integer with all prime factors lying in $S$. Then (1) is asserting that the $m+k$ integer $S$-units $a^{x_1}, \dots, a^{x_m}, -b^{y_1},\dots,-b^{y_k}$ sum to zero. The claim now follows from the following result (a consequence of the Schmidt(-Schlickewei) subspace theorem):
Theorem Let $S$ be a finite set of primes, and $n \geq 1$. Then up to projective equivalence $(z_1,\dots,z_n) \mapsto (\lambda z_1,\dots,\lambda z_n)$, there are only finitely many solutions to the equation $z_1+\dots+z_n=0$ where $z_1,\dots,z_n$ are integer $S$-units with the property that no non-trivial subsum of these integer $S$-units sum to zero.
See for instance Corollary 1.1 of these notes of Evertse for a proof. (The fact that $a,b$ are not rational powers of each other ensures that each projective class of solutions to $z_1+\dots+z_{k+m}=0$ can generate at most one solution to (1).)
Remark 1. One can illustrate the use of the subspace theorem by focusing on the simple example $3^x = 2^y + 1$. Here we use a special case of the Schmidt--Schlickewei subspace theorem: For any $\delta>0$, and up to projective equivalence, the number of integer solutions $z_1, z_2$ to the inequality
$$ \frac{\|z_1\|_\infty \|z_2\|_\infty}{\|z\|_\infty} \frac{\|z_1\|_2 \|z_2\|_2}{\|z\|_2} \frac{\|z_1+z_2\|_3 \|z_2\|_3}{\|z\|_3} \leq H(z)^{-2-\delta}$$
is finite, where $\|z_i\|_p$ is the $p$-adic valuation of $z_i$ (equal to $p^{-\nu}$ if $z_i$ is divisible by exactly $\nu$ powers of $p$), $\|z\|_\infty = |z|$ is the Archimedean valuation, $\|z\|_v := \max(\|z_1\|_v, \|z_2\|_v)$, and $H(z)$ is the absolute height of $z$ (which, if $z_1,z_2$ are coprime, is just $\max(|z_1|, |z_2|)$). But if one plugs in $z_1 = 2^y$ and $z_2=1$ here for some solution to $3^x = 2^y + 1$, one can calculate that the left-hand side decays like $H(z)^{-3}$, so there are only finitely many solutions to $3^x=2^y+1$.
Remark 2. Due to the use of the subspace theorem, this result is ineffective. It would be interesting to get a more effective bound on the solutions here. I experimented with trying to use Baker's theorem, but could not use this theorem to cover all cases (the gaps between consecutive $x_i$ or $y_j$ seem to play a role in whether this theorem is helpful).