Suppose one is given the spacetime $(M,g)$ where $M$ is a fixed differentiable manifold and $g$ is a Lorentzian metric whose local expression is:
$$g= -(dt + a \, d \phi)^2 + d\rho^2 + \kappa^2 \rho^2 \, d\phi^2 + dz^2 \ \text{where} \ \ a > 0$$
This is the spacetime of an infinite straight Spinning Cosmic String.
Suppose that the spacetime $(N,h)$ is locally isometric to the spacetime $(M,g)$.
Since there are distinct definitions of local isometry in the mathematical literature it's better to clarify one's definition explicitly:
Spcetime $(M,g)$ is locally isometric to $(N , h)$ if and only if each point $p \in M$ has an open neighborhood $U_p$ and an open neighborhood $V \subset N$ and a diffeomorphism $f: U_p \rightarrow V$ such that: $$g \big |_{U_P}=f^*h \big|_{U_p}$$
The question is:
what can in general be extracted anout the differentiable manifold $N$ by a particular choice of $M$ inclusive of its differential structure?
This applies both to the differential structure over the manifold $N$ and its topology.