It is a very well understood problem to compute the size of the maximum independent set in a uniform hypergraph (in terms of extra conditions).
My question is the following: what is known for hypergraphs that are not uniform? I know the very elementary probabilistic proof by Spencer in his 1972 paper "Turán's theorem for k-graphs" (which uses 1st moment method) but I do not know if there is some later work in which the method is refined somehow (also, maybe using extra assumptions on the hypergraph).