A Lie monoid is a monoid, together with a structure of a smooth manifold (possibly with a boundary), such that the monoid multiplication is smooth.
If all left (or right) translations in a Lie monoid $M$ have full rank at the identity $e$, then the monoid is necessarily parallelizable, since any basis of $T_eM$ may then be extended to a left-invariant (or right-invariant) global frame for $TM$. In particular, this holds for any Lie group. Furthermore, any Lie monoid $M$ that admits an injective immersive homomorphism $\phi\colon M\rightarrow G$ into a Lie group $G$, is parallelizable. That is, any Lie submonoid of a Lie group is parallelizable.
However, left and right translations in a Lie monoid may not have full rank at identity, indicating that in general, a Lie monoid may not be parallelizable. The question hence reads: Do non-parallelizable Lie monoids exist?
A useful insight to this question stems from the theory of H-spaces. Since H-spaces are generalizations of topological monoids, and the only spheres that admit a H-space structure are parallelizable, spheres don't admit such a Lie monoid structure. Due to cohomology, projective spaces are also disqualified. Furthermore, there exist H-spaces which are not parallelizable (see e.g. Browder, Spanier: H-spaces and duality, Pac. J. Math. 12, 411-414 (1962). ZBL0112.14502.), but the given example is quite involved.