$\DeclareMathOperator\SO{SO}\DeclareMathOperator\O{O}\DeclareMathOperator\SU{SU}\DeclareMathOperator\Lift{Lift}$The subgroup of $ \SO(n) $ of signed permutations has order $ n!2^{n-1} $. I will call this group $ W_n $.
I think that $ W_n $ fails to be maximal if and only if $ n=2^k $ is a power of $ 2 $. Indeed it seems to me that $ W_{2^k} $ normalizes a certain extraspecial subgroup $ E \subset \SO(2^k) $ of order $ 2^{2k+1} $. I think the full normalizer of $ E $ is generated by the signed permutations together with tensor products involving $$ \frac{1}{\sqrt{2}}\begin{bmatrix} 1 & 1 \\ 1 & -1 \end{bmatrix} $$ Is this true?
Context:
$W_3 \cong S_4$ is isomorphic to the symmetric group on 4 letters and $ W_3 $ is maximal.
$W_2 \cong C_4$ is the cyclic group of order 4. So $ W_2 $ is not maximal.
And for $ W_4 $ we have a chain of strict containments $$ W_4 \subsetneq \Lift(S_4 \times S_4) \subsetneq \SO(4) $$ where $\Lift$ denotes the Lift through the double cover $ \SO(4) \to \SO(3) \times \SO(3) $. So $ W_4 $ is also not maximal.