Let $\mathfrak g$ be a semisimple Lie algebra over $\mathbb C$, $\rho : \mathfrak g \to \operatorname{End}(V)$ a finite-dimensional irreducible representation and $x \in \mathfrak g$ regular with centralizer $Z$.
Does $\rho(Z)$ consist of polynomials in $\rho(x)$?
Examples where I know this is true:
$x$ is semisimple: then $Z$ is a Cartan subalgebra, $\rho(x)$ acts by distinct scalars on the weight spaces $V_\lambda$ and the claim follows from Lagrange interpolation. (This argument doesn't work: the scalars need not be distinct.)- $\mathfrak g = \mathfrak{sl}_n$ and $\rho = $ standard rep., because $x$ regular implies its minimal polynomial has degree $n$ so the (trace $0$) polynomials in $x$ give all of $Z$.