My question is about whether it's more natural to see manifolds as ringed spaces or as locally ringed spaces. I think I have arguments for both points of view.
On the one hand, it's reasonable to expect functions that do not vanish at some point $p$ to be invertible in a neighbourhood of $p$. This is precisely saying that the stalks of the structure sheaf should be local rings.
On the other hand, limits and colimits of manifolds (when they exist), coincide with those taken in the category of ringed spaces, but not with those in the category of locally ringed spaces.
Another possible point is that I know that the category of manifolds is a naturally a full subcategory of $\mathsf{LRS}/\mathbb{R}$ but I'm not sure if it's also a full subcategory of $\mathsf{RS}/\mathbb{R}$.