Let $k \ge 1,B \ge 2$ integers and $\zeta^{(k)}(s)$ denote the $k$-th derivative of Riemann zeta function. For real $x$, let $[x]$ denote the nearest integer to $x$.
Conjecture 1: For all $n \ge 1,[\zeta^{(n)}(1/2)]= -2^{n+1} n!$
Conjecture 2: For all $k \ge 1,B \ge 2$ we have $[\zeta^{(k)}(1-1/B)]= -B^{k+1}\cdot k!$ and $\zeta^{(k)}(1-1/B)$ is very close to integer.
sagemath code per request:
def zetania2(LK=10,prec=100,bb=[3,5]):
"""
zeta^(k)(1-1/B), near to integers
"""
import mpmath
mpmath.mp.pretty=1
mpmath.mp.dps=prec
pre2=10
for B in bb:
l0=[]
lerr=[]
for k in range(1,LK+1):
T=mpmath.zeta(1-1/mpmath.mpf(B),derivative=k)
N=mpmath.nint(T)
N2= -B**(k+1) * factorial(k)
l0 += [N-N2]
print(B,l0)