Let $(R,\mathfrak m)$ be a local noetherian ring, and $M$ an arbitrary $R$-module. Suppose that $\mathrm{Tor}_1(M,R/\mathfrak m)=0$. Does it follow that $M$ is flat?
The answer is positive when $M$ is finitely generated, or when $\mathfrak m$ is nilpotent (that is, $R$ is artinian). The same can be said if there is a local homomorphism of local rings $R\to S$ and $M$ is a finitely generated $S$-module (local criterion for flatness).
If one assumes that $\mathrm{Tor}_1(M,R/\mathfrak p)=0$ for every prime ideal $\mathfrak p\subset R$, then $M$ is flat.
There are reasonable doubts that the answer is positive in general, but I don't have a counterexample.