Let $\mathcal F$ be a locally constant sheaf with values in $\mathbb C$ on a nice enough space, say a compact manifold. The etale space of $\mathcal F$ defines a covering $p: \tilde X \to X$.
Is there any relation between the (cech) cohomology $H^*(X, \mathcal F)$ and the (singular) cohomology $H^*(\tilde X, \mathbb C)$?