For integers $n \geq k \geq 1$ let $$H(n,k) := \sum_{1 \leq i_1 < \cdots < i_k \leq n} \frac1{i_1 \cdots i_k}$$ be the $k$-th elementary symmetric function of $\tfrac1{1},\tfrac1{2}, \ldots, \tfrac1{n}$.
Erdős and Niven [1] proved that $H(n, k)$ is an integer only for finitely many $n$ and $k$, and subsequently Chen and Tang [2] showed that $H(1,1)$ and $H(3,2)$ are the only integral values.
My question is: "Is it true that $H(n,k)$ is a $2$-adic integer only for finitely many $n$ and $k$?"
Note the two extremal cases: $H(n, 1) = 1 + \frac1{2} + \cdots + \frac1{n}$, the $n$-th harmonic number, which is well-known to be a $2$-adic integer only for $n = 1$; and $H(n,n) = 1 / n!$, which obviously is a $2$-adic integer only for $n = 1$. Note also that the $p$-adic valuation of $H(n,k)$ has been studied in [3].
Of course one may ask the more general question: "Given a prime number $p$, is it true that $H(n,k)$ is a $p$-adic integer only for finitely many $n$ and $k$?" However, an old and still open conjecture of Eswarathasan and Levine [4] states that for any prime $p$ the harmonic number $H(n,1)$ is a $p$-adic integer only for finitely many positive integer $n$. Hence, this latter question seems to be too difficult for the current methods.
[1] P. Erdős and I. Niven, Some properties of partial sums of the harmonic series, Bull. Amer. Math. Soc., 52 (1946), 248–251.
[2] Y.-G. Chen and M. Tang, On the elementary symmetric functions of $1, 1/2, . . . , 1/n$, Amer. Math. Monthly, 119 (2012), 862–867.
[3] P. Leonetti and C. Sanna, On the p-adic valuation of Stirling numbers of the first kind, Acta Mathematica Hungarica 151 (2017), 217–231.
[4] A. Eswarathasan and E. Levine, $p$-integral harmonic sums, Discrete Math., 91 (1991), 249–257.