This is a somewhat vague question, but I think it is not too open-ended and should admit well-circumscribed answers by specialists in operator algebras.$\newcommand{\Cst}{{\rm C}^*}$ It arises from some background reading I was doing while working on a different area/problem.
For sake of simplicity I'll restrict to unital separable $\Cst$-algebras, although I think everything can be discussed more generally with appropriate modifications. $\otimes$ will denote the completed minimal tensor product of $\Cst$-algebras.
Definition. A (unital, separable) $\Cst$-algebra $A$ is said to have approximately inner flip if there is a sequence of unitaries $(u_n)\subset A\otimes A$ such that $u_n(x\otimes y)u_n^* \to y\otimes x$ for every $x,y\in A$. It is said to have approximately inner half-flip if $u_n(x\otimes 1_A)u_n^* \to 1_A\otimes x$ for all $x\in A$.
It's known that having a.i. half-flip already imposes some fairly strong restrictions on $A$, such as being simple and nuclear. We also know that ${\mathcal O}_2$ and ${\mathcal O}_\infty$ have a.i. flips.
From a quick look at the 1978 paper of Effros and Rosenberg, I gather that these properties are analogues of von Neumann algebraic properties of the hyperfinite ${\rm II}_1$ factor. What I would like to know is: why is it interesting/important to characterize those $\Cst$-algebras with a.i. (half-)flip? and if we can show that a given simple, nuclear $\Cst$-algebra has a.i. (half-)flip, what further structural consequences does one typically hope to deduce?
I guess part of what I would like to find out is whether we can think of these properties in any of the following ways:
1) "goes unseen by many of the usual invariants"
2) "has some kind of homogeneity not shared by general unital nuclear simple $\Cst$-algebras"
3) "looks like one of several standard examples on a short list".
Of course, if any or all of these three claims are wide of the mark, I'd welcome any clarifications or corrections.