Q1: Let $D^n$ ($n\geq 1$) be the n-dimensional open disk. If $D^n-\{0\}$ is homeomorphic to $X\times (0,1)$, for some topological space $X$, does it necessarily follow that $X$ is homeomorphic to $S^{n-1}$?
Q2 Let $Z$ be a topological space. What kind of assumptions can you impose on $Z$ in order to have the cancellation property for all (may be here one should impose some additional conditions on the cartesian decomposition) cartesian decompositions of $Z$, i.e., if $Z\simeq X\times Y$ and $Z\simeq X\times Y'$ then $Y\simeq Y'$