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There are (at least) two approaches to K-homoology: one is via the so called dual algebra which is due to Paschke. The second is via the Fredholm modules and is due to Kasparov. In Nigel Higson's book there is the note that the second approach is more flexible. I wonder what exactly does it mean: to be more precise, in the first treatment there is a assumption that the underlying $C^*$-algebra is separable and as far as I understood some properties and proofs, this assumption is heavily used. Namely, one needs the so called ample representation in order to prove that the dual algebra (essentially) doesn't depend on the representation.
When it comes to discussing Fredholm modules, author assumes also that the underlying $C^*$-algebra is separable however he points out that the definition of Fredholm modules can be stated for general $C^*$-algebras. So my question is the following:
Question: is it true that one can define $K$-homology groups for all $C^*$-algebras but only via Fredholm modules. So in other words, the dual algebra aproach is not proper to define $K$-homology groups for general $C^*$-algebras?

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    $\begingroup$ I cannot answer your question, but I am currently collaborating with Dr. Pere Ara, from the Universidad Autónoma de Barcelona ([email protected]), who probably can enlighten your way. $\endgroup$ Commented Sep 20, 2014 at 15:07

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The main problem with dual algebras for non-separable C*-algebras is that they need not be functorial. Given representations $\rho_A \colon A \to \mathcal{B}(H_A)$ and $\rho_B \colon B \to \mathcal{B}(H_B)$ and a $*$-homomorphism $\phi \colon A \to B$, one wants to define the induced map $\phi_* \colon \mathcal{D}(B,\rho_B) \to \mathcal{D}(A, \rho_A)$ by $\phi_*(T) = VTV^*$ where $V \colon H_B \to H_A$ is an isometry such that $V^* \rho_A(a) V$ is equal to $\rho_B(\phi(a))$ modulo compact operators. Such isometries are constructed using Voiculescu's theorem, which requires that $A$ is separable. Without functoriality the whole theory pretty much collapses; for instance, one proves that K-homology is independent of the ample representation used to define the dual algebra by arguing that the K-theory map induced by $\phi_* \colon \mathcal{D}(B, \rho_B) \to \mathcal{D}(A, \rho_A)$ is independent of the isometry $V$.

For Kasparov's model of K-homology, you don't run into this problem: if $(\rho, H, F)$ is a Fredholm module over $B$ then $(\rho \circ \phi, H, F)$ is a Fredholm module over $A$. Still, there are problems: without Voiculescu's theorem you don't have the excision theorem in either model (at least the standard proof doesn't work) and without excision you don't have long exact sequences.

None of this should be too much of a concern, however - most C*-algebras for which K-theory is useful are separable (e.g. $C(X)$ for $X$ compact, crossed products of $C(X)$ by a locally compact group action). The main source of non-separable C*-algebras is the theory of von Neumann algebras, and K-theory/homology doesn't tell you anything about von Neumann algebras anyway.

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    $\begingroup$ I completely agree with Paul. One difficulty of working with dual algebras is illustrated by my old paper: projecteuclid.org/download/pdf_1/euclid.pjm/1102720214 in which I tried to get a new proof of the Pimsner-Voiculescu 6-terms exact sequence... but I could only get a 5-terms sequence! $\endgroup$ Commented Sep 20, 2014 at 20:31
  • $\begingroup$ Some time ago I posted the following question, concerning K-theory: mathoverflow.net/questions/169270/… One can form the same question but for K-homology instead of K-theory. So what would be the answer: which (pairs of) abelian countable groups can be realized as K-homology groups? $\endgroup$
    – truebaran
    Commented Sep 20, 2014 at 23:47
  • $\begingroup$ I wonder whether the Voiculsecu's theorem also holds when $A$ is non-separable? $\endgroup$
    – math112358
    Commented Feb 13, 2022 at 11:57

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