Consider a partially ordered set $P$, and two upper sets $U_1$, $U_2$ in this poset.
What are some natural ways to measure how equal these two upper sets are? This question arise naturally in the study of proteins which upper closed sets.
Of course, all measures on sub-graph similarity in graphs can be applied here, but perhaps using that these are upper-closed sets in a poset, make some constructions more natural.
What similarity means, is of course depending on the similarity measuring function, but say $sim(U_1,U_1)$ should be big, and $sim(U_1,U_2)$ is small if $U_1$ and $U_2$ if the overlap between $U_1$ and $U_2$ is small.