This question is related to my question "Forcing with c.c.c forcing notions, Cohen reals and Random reals".
A natural way to answer Prikry's conjecture is to build a c.c.c. forcing notion which adds a minimal generic real.
I arrived to the idea of constructing such a forcing notion by considering the following:
1) Mathis forcing at $\omega$ is essentially the same as Prikry's forcing at some measurable cardinal,
2) Recently, a minimal Prikry type forcing at a measurable cardinal is constructed by Koepke-Räsch-Schlicht (see "A minimal Prikry-type forcing for singularizing a measurable cardinal, J. Symbolic Logic Volume 78, Issue 1 (2013), 85-100." and also Is Prikry forcing minimal? ).
So a natural idea is to define a version of the above forcing for $\omega$. It turns out to me that such a forcing is constructed many years ago by Judah-Shelah in "Forcing minimal degree of constructibility" and there it is shown that under $CH$ we can choose nice ultrafilters so that the resulting forcing adds a minimal generic real which is minimal.
Let me describe the forcing I have in mind: Let $(A_n: n<\omega)$ be a partition of $\omega$ into infinite sets and for each $n$ let $U_n$ be a non-principal ultrafilter over $A_n$. Let $\mathbb{P}$ consists of all pairs $(t, T)$ where $T \subseteq [\omega]^{<\omega}$ is a tree with trunk $t$ and for all $t \unlhd u\in T$ (where $\unlhd$ denotes end-extension relation) $Suc_T(u) \in U_{max(u)}.$ We define $(t, T) \leq (s, S)$ iff $T \subseteq S$ and $(t, T) \leq^* (s, S)$ iff $T \subseteq S$ and $t=s.$ The following can be proved easily:
1) $(\mathbb{P}, \leq)$ satisfies the c.c.c.,
2) $(\mathbb{P}, \leq, \leq^*)$ satisfies the Prikry property,
3) Let $G$ be $\mathbb{P}-$generic over $V$ and let $f_G=\bigcup \{t: \exists T, (t, T)\in G \}.$ Then $f_G$ is a real,
4) Suppose $d \subseteq f_G$ is infinite, then $V[d]=V[f_G]$ (the proof is the same as in the proof of Proposition 4.4 in Koepke-Räsch-Schlicht paper).
Question. Is it consistent with $ZFC$ that there is no sequence of ultrafilters as above such that the corresponding forcing defined above adds a minimal generic real?
Note that in such a model $CH$ or $MA+\sim CH$ should fail.
Remark 1. If we can show that the forcing does not add a minimal generic real when all of our ultrafilters are on the same class of near-coherence ultrafilters, then the answer to question 1 will become positive, as it is consistent that there is just one class of near-coherence non-principal ultrafilters.
Remark 2. As pointed out by Dorais, if all of the ultrafilters are RK equivalent, then the resulting forcing does not add a minimal generic real.