Let $N(T)$ be the number of complex zeros of $\zeta(s)$ with imaginary part between $0$ and $T$, and let $N_k(T)$ be the analogous counting function for the $k$th derivative $\zeta^{(k)}(s)$. Based on numerical evidence for $T<100$, Spira conjectured in 1965 ("Zero free regions of $\zeta^{(k)}(s)$, J. London. Math. Soc. v. 40 1965 pp. 677–682) that $$ N(T)=N_k(T)+[T\log(2)/(2\pi)]\pm 1. $$ Berndt later showed that $$ N(T)=N_k(T)+T\log(2)/(2\pi)+O(\log(T)). $$
Is Spira's original conjecture still open? (I don't expect this is true; finding a counterexample will be a nice project for an undergraduate.)