Mendelson, in Introduction to Mathematical Logic, 4th ed, 1997, had a more elegant approach to comprehension than predecessors, in my opinion.
With $x\in\mathbf{V}$ short for $\exists y(x\in y)$, and $\alpha$ any formula in the language of set theory (possibly without =), use the axiom schemas:
SE: $\exists y(y=\{x|\alpha\})$ and CA: $\forall x(x\in\{x|\alpha\}\leftrightarrow x\in \mathbf{V}\wedge \alpha)$
A class is a set just if it is a member of $\mathbf{V}$. Mendelson goes on and develops NBG set theory on the basis of these, and further assumptions.
Question: Have others explored other set theories, with an approach as this?