First a disclaimer. This is an old question that I considered years ago and that I recently remembered. Since I am no longer in active research it may be considered as 'idle curiosity', although I feel I could probably learn a good deal from an answer (and maybe others could find it instructive as well).
Now the question. Are there any examples of elliptic curves $E/\mathbb{Q}$ (or failing that over some other number field) of rank $0$, and an open subvariety $X\subset E$, such that $$ X(\mathbb{A}_\mathbb{Q})^{\operatorname{Br}(X)} = \varnothing? $$ Here the left-hand side denotes the Brauer-Manin set of $X$.
Or more generally still, is it at all possible to use Brauer-Manin obstructions to prove the non-existence of rational points on curves outside of some closed (proper and non-empty) subset?
The main problem that I recall having is that if one deals with Brauer classes on $X$ that are ramified (i.e. that do not come from $\operatorname{Br}(E)$), the evaluation map $$ \operatorname{ev}_X : X(\mathbb{A}_\mathbb{Q}) \times \operatorname{Br}(X) \to \mathbb{Q}/\mathbb{Z} $$ is hard to describe, since for $\mathscr{A} \in \operatorname{Br}(X)$ with $X$ non-proper there are in general infinitely many primes such that the local evaluation map $\operatorname{ev}_{\mathscr{A},p} : X(\mathbb{Q}_p) \to \mathbb{Q}/\mathbb{Z}$ is not identically zero (this in contrast to the case where $X$ is projective). The usual way of computing Brauer-Manin obstructions is that one exhibits a set of Brauer classes $\mathscr{A}_i$ and shows that the images of the maps $\operatorname{ev}_{\mathscr{A}_i} :U_i \to \mathbb{Q}/\mathbb{Z}$ are disjoint from $0$, for some partition $U_i$ of $X(\mathbb{A}_{\mathbb{Q}})$. But this becomes difficult when $X$ is non-proper, since one needs to determine the images of an infinite set of local evaluation maps $\operatorname{ev}_{\mathscr{A}_i,p}$ (for each $i$). (I don't even know whether it somehow follows from this that the examples I am asking for simply do not exist.)