I don't know why there is no investigation of the cancellability of quotients in category of modules. What I mean by cancellability of quotients in category of modules is the following :
Let $R$ be a ring (for simplicity, commutative) and $M$ be an $R$-module. We say that $M$ is numerator-cancellable if for every $R$-modules $M_1$ and $M_2$ and for every monomorphisms $f_1: M_1\to M$, $f_2: M_2\to M$, if the quotient modules $M/f_1(M_1)$ and $M/f_2(M_2)$ are isomorphic, then $M_1$ and $M_2$ are isomorphic.
For example, if $K$ is a commutative field, then we can prove easily that every $K$-module (ie. K-vector space) is numerator-cancellable. We can see also that any simple $R$-module is likewise numerator-cancellable. I think that is also true (under some restricted hypothesis) for the semi-simple $R$-modules.
Is there any reference concerning the problem ?