Let $p:B\to BO$ be a fibration. We say that a manifold has a $B$-structure if its stable tangent bundle lifts to $B$. I am interested in the question of whether there exists, for a given even dimension dimension, a manifold with odd Euler characteristics. Note that Euler characteristic of $2$ can always be achieved, using the sphere $S^{2k}$.
For example, in the case of $BSpin\to BO$, the odd Euler characteristics can be achieved in dimensions $0\pmod{8}$ (for example the quaternionic projective plane HP^2) and cannot be achieved in all other dimensions $\pmod{8}$.
One possible approach might be through characteristics classes. Recall that for a $2k$-dimensional manifold $M$, the middle Wu class $v_k\in H^k(M;\mathbb{Z}/2)$ satisfies the following equation
$$x^2=v_kx\quad \forall x\in H^k(M;\mathbb{Z}/2)$$
in particular we know that if $v_k=0$, then the intersection form of the manifold $M$ is even, i.e. $\langle x^2,[M]\rangle\equiv 0$, then the middle cohomology has an even rank and so the Poincare duality gives that $M$ necessarily has even Euler characteristisc.
EDIT: as prof. Albanese suggested the same conclustion can be achieved if $p^*w_{2k}=0$ in $H^{2k}(B;\mathbb{Z}/2)$ because $\chi(M)\equiv \langle w_{2k}(M),[M]\rangle\pmod{2}$.
Now we might be able to prove that a specific $B$-structure on a manifold forces the class $v_k$ to vanish, as was the strategy of the paper https://arxiv.org/abs/1704.06607.
My question is: In the cases, where the above method does not help, how could one try to solve the question for a given $B$?