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What do you mean by important breakthroughs? For understanding my question see these levels in math research: ordinary paper < good quality paper < systematic papers answering some important conjectures < works that lead to a new sub-branch of math (like Ricci flow inside of differential geometry/topology) < works that discover/introduce a new branch of math (such k-theory and category theory) and so on. There is also a breakthrough prize in math. Which one is related to your post?
The Milnor book in 1963 is another example. I wonder how they write sub(p)script with typewriter? how they change the font size or math/Greek special symbols?