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I can't believe that Python and its vast scientific application libraries are not mentioned in this thread. Let me be little bit bias and mention projects like PyDSTool. What makes Maple or Mathematica language simpler than Python? Similarly time proven proprietary computer algebra system MuPad now a part of MATLAB is not mentioned. FreeMat, the cleanest (other two being GNU Octabe and Scilab) reimplementation of MATLAB API, is also not mentioned.