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Number of $\{0,1\}$ matrices with distinct rows and distinct columns

How many $M\in\{0,1\}^{r\times c}$ are there such that each row and each column of $M$ is distinct?

How many classes of matrices in $\{0,1\}^{r\times c}$ up to permutation equivalence are there such that each matrix in every class has each row and each column distinct?

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