Let $X$ be a regular projective (complex) surface and $S$ be a finite set of closed points on $X$. Denote by $j:X\backslash S \to X$ the open immersion. Assume further that $H^1(\mathcal{O}_X)=0$. Is $H^0(R^1j_*\mathcal{O}_{X \backslash S})=0$?