I often see conditons like $\pi_{2}G\not=0$ in reading old papers on Lie groups(need to double check in light of the comment). I want to ask why we need this condition and how the higher dimensional homotopy group matters. I have `read' most of available introductory graduate level textbooks on representation theory of Lie group and Lie algebra like Fulton and Harris, and I seldom(if ever) see higher diemsional homotopy groups enters into the discussion. I remember when I ask this to my undergraduate advisor, he responded that this is a "common condition" so we should not worry about it. Given the fact that most Lie groups are of huge dimension, it seems reasonable not to worry about if it is 2-connected. But now thinking in retrospective, I am wondering if the matter is this simple. Also, for practical purposes is there a practical way to compute it by its representations? For example $Sp(14,\mathbb{C})$ or $SO(5)$?