Well, the answer of the question in the title in certainly Yes, many things in fact, but let me be more precise.
In 1958, Serre gave a Bourbaki talk on the recent works of Iwasawa on class groups in towers of cyclotomic extensions, in which he presented Iwasawa's theorems on the growth of $\operatorname{Cl}(\mathbb{Z}[\zeta_{p^{n}}])[p^{\infty}]$ in terms of what we nowadays call Iwasawa's $\lambda,\mu$ and $\nu$ invariants. At the end of the introduction, Serre writes that the $\mu$-invariant has been computed (or so it seems, he adds a bit mysteriously) for $p=37,59$ and $67$, the first three irregular primes, which are the first three primes for which these invariants cannot all be trivial.
70 years later and with the help of the Iwasawa Main Conjecture, it is quite easy to carry such a computation, and trivial to do so with electronic aid: one computes a bunch of Bernoulli numbers, deduce from that an approximation of the $p$-adic $L$-function. The Iwasawa Main Conjecture (proved by Mazur-Wiles) then translates this approximate computation to structure properties of $\operatorname{Cl}(\mathbb{Z}[\zeta_{p^{n}}])[p^{\infty}]$. Relying on both, computing $\lambda,\mu$ and $\nu$ for smallish irregular primes is a matter of seconds.
However, even with quite competent electronic aid, trying to compute these invariants directly (that is to say for direct naïve computation of the structure of the class groups in the towers, and by naïve here I mean using the best general algorithms, rather than anything particular to the $p$-part of the class group of the particular cyclotomic field $\mathbb{Q}(\zeta_{p^n})$) strains my computing resources (even checking that the order of the class group of $\mathbb{Q}(\zeta_{67})$ is divisible only once by $67$ is not something my computer seems to find particularly easy).
I suspect that two main differences between what I'm telling my computer to do and what Iwasawa (and/or others) did then is that 1) I am trying to compute the full structure of the class group and not just the $p$-torsion part and 2) I am trying to establish the full structure, and not just proving that $\mu$ vanishes.
Nevertheless, I would be glad to know the answer to the following question
How did Iwasawa himself (or others) compute the structure or at least the structure of the $p$-torsion-part of the class groups of say $\mathbb{Q}(\zeta_{59^n})$ or $\mathbb{Q}(\zeta_{157^n})$ for small $n$ back in the 1950s, since apparently he (or others) knew enough about them to deduce something about $\mu$?